Scientist - Small Molecule Process Development

Scientist - Small Molecule Technology

Job Description

• • Develop safe, robust, scalable, and efficient manufacturing processes for intermediate and Active Pharmaceutical Ingredients (APIs) suitable for both pilot plant and commercial scale production.

  • Performing literature search and identifying various synthetic routes for process development.

  • Promotes the use of novel experimental approaches within sub-function; routinely investigates/creates innovative processes, hypotheses and methodologies.

  • Knowledge of interpretation of structures using spectral techniques like NMR, IR & Mass spectra.

  • Planning and Performing experiments as per process governance (Lab feasibility, Optimization, Pre-validation, CPP and Validation)

  • Performing What if studies, stress studies, holding time studies, Mass balance, recovery studies and scale up studies.

  • Encountering the process challenges on time and supporting production teams for scale up activities.

  • Handling of business critical / supply chain critical related investigational projects on fast track

  • Participate in brainstorming activity for the project in identifying scope of improvement

  • Responsible for making necessary scientific statutory documents for the lab execution of a given project

  • Designing experiments based on the project /business requirement in varying scale as per the needs

  • Perform data analysis, interpret the data of them and provide scientific rationale for the experiments

  • Support the next level manager in providing the cost estimates associated with R&D project proposals

  • Summarize the experimental results and present to the next level managers for discussion

  • Prepare Technical project updates with precious data as per the business meeting requirement regularly

  • Knowledge on ICH guidelines.

  • Willingness to learn and apply new technology/ tools to meet process / business needs

  • Co-ordinate with Analytical, Process safety, Process engineering teams on the project discussions and support the need of them to drive the project

  • Utilization of electronics tools (Biovia eLN, GDMS, LIMS etc.,)

  • Partner closely with other CRD scientists, Process Engineers, Process Safety Chemists, Crystallization Technologists, Pilot Plant facility, Analytical, Formulation and manufacturing colleagues at Global Pfizer sites as required.

  • Responsible for instrument qualification across the CRD labs (coordination with instrumentation team, quality team)

  • Ensure compliance with cGMP /GSP procedures and practices

  • Ensure effective safety systems are implemented in the premises

  • Perform other tasks as per the dynamic business requirement

QUALIFICATION

• Ph.D in the field of Organic Chemistry.

• Demonstrated capabilities and experience in performing chemical reactions, structure characterizations, basic understanding of chromatography, Crystallizations, Basic safety principles, Basic quality principles, basic understanding of analytical techniques.

• Experience and demonstrated competencies in working with teams in a matrixed organization, building and nurturing relationships and effective engagement resulting in successful outcomes.

• Candidate should have skill in preparing the technical reports and adherence to compliance.

  
Work Location Assignment: On Premise

 

 

 

  
Work Location Assignment: On Premise

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Research and Development