Senior Scientist - Protein Biology and Antibody Development

Scientist III, Protein Biology

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)

Job Description

About the company

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with annual revenue of approximately $44 billion. Our Mission is to enable our customers to make the world healthier, cleaner, and safer. Whether our customers are accelerating life sciences research, solving analytical challenges, growing efficiency in their laboratories, improving patient health through diagnostics, or developing and manufacturing life-changing therapies, we are here to support them. Our distributed team delivers an outstanding combination of innovative technologies, purchasing convenience, and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD. Our Innovative Laboratory technologies & Services makes it easier for customers.

About Team: Antibody team

The antibody team is involved in development and engineering of antibodies, with a deep focus on reagent quality and specificity. The core activities of team include design, development, purification, conjugation and testing of antibodies in a variety of immunoassay applications using state of the art technologies. The goal of the program is advanced product development and creation of product specific information to promote research use.

Role & Responsibilities

Role:

To be an integral part of an antibody development team with a focus on performance and specificity using innovative molecular, protein, and cell biology methods.

Responsibilities:

• Contribute in a fast- paced environment towards Antibody development & Validation
• Project leadership role in new antibody development programs with experimental planning and execution to meet the program milestone.
• Lead team of scientists in matrix style operation, provide technical and operational supervision. Mentoring and training junior scientists.
• Design and experimental execution, interpreting data and data presentation to the stakeholders.
• Drive ideation within teams to enable development of successful protocols for effective transfer to operation teams.
• Serve as subject matter expert in antibody discovery and biophysical characterization to provide inputs and guidance towards driving innovation and cross team collaborations.
• Knowledge of product commercialization processes from concept to launch including early feasibility, development, and validation phases.
• Good scientific writing skills, establishing technical protocols for effective transfer to operations teams.
• Good documentation practice is a must to maintain data integrity and accuracy.
• Delivering high quality results according to project schedule in support of product commercialization from concept to launch including early feasibility, development and validation phases.

Candidate Requirement:

Education & Experience levels:

Applicants should have a PhD with greater than 7 years’ experience in a life sciences field with a strong focus on protein biology. Minimum 3-4 years of Industrial experience is required. Prior people management experience is preferred.

Nature of experience:

• Extensive experience in the antibody development and engineering including hybridoma, single B cell, phage display and other recombinant antibody platforms
• Extensive experience and familiarity with antibody or protein design and biophysical characterization using state of the art methodologies including SPR and BLI
• Expertise in antibody screening and characterization methods including affinity measurements and epitope binning
• Experience in the field of molecular biology, protein expression, protein purification, protein-protein interaction, protein structure -function relationships, and immunogen designs
• Proficient in molecular biology workflows such as high-throughput cloning, plasmid vector construction, and next generation sequencing
• Thorough in biochemical and immunoassay workflows such as ELISA, SDS-PAGE, Western blotting, IF, IHC, proximity ligation and extension assays
• Expertise in development of conjugation chemistries or performing antibody conjugations is desired
• Ability to provide technical trouble shooting to resolve scientific problems.
• Experience in authoring and optimizing standard operating procedures with a focus on reproducibility
• Skills for identifying deviations from expected outcomes, problem solving and suggesting alternatives
• Excellent written and verbal presentation skills
• Experience in leading product launches through knowledge and application of product commercialization processes including feasibility, development, and validation stages
• Proven leadership skills and ability to work alongside colleagues from different backgrounds
• Experience with leading and mentoring people either with or without direct reporting structure
• Strong, independent understanding of standard and emerging research protocols and techniques are preferred. GLP experience is a must.

The successful candidate will be self-motivated and a self-starter who is excellent at learning and applying new concepts for process or product improvements, possess excellent oral and written communication skills to connect to peers and leadership, and will be an excellent teammate with the ability to work with diverse colleagues.

Thermo Fisher Scientific is an equal opportunity employer and value diversity at our company. All qualified applicants will receive consideration for employment without discrimination basis race, color, religion, sex, sexual orientation, gender, gender identity or expression, national origin, protected veteran status, age, genetics, pregnancy, disability or any other legally protected status. Thermo Fisher Scientific aligns with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!

ThermoFisher is committed to crafting a diverse work environment that values and respects individuals from all backgrounds. Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

Experience Level

Senior Level